簡要描述:氣道阻力和肺順應性檢測系統(tǒng)ResistanceandCompliancePlethysmographs采用侵入式氣道力學對老鼠的肺功能進行檢測
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氣道阻力和肺順應性檢測系統(tǒng) Resistance and Compliance Plethysmographs 采用侵入式氣道力學對老鼠的肺功能進行檢測。
· 檢測過程做一個有創(chuàng)型的手術;
· 檢測大鼠、小鼠的多種肺功能參數(shù),如:呼吸速率、潮氣量到氣道阻力和肺順應性。
· 系統(tǒng)通過測量端口壓、跨肺壓或胸膜壓以及氣道中氣體流速等參數(shù),直接得出氣道阻力、肺順應性、潮氣量等肺功能指標參數(shù);
· 血壓和心率的檢測可以用來研究心血管反映,也可用來判斷動物狀態(tài);
主要特點:
· 可選擇多種給藥方式(頸、尾靜脈注射、霧化給藥)
· 可同時檢測多種參數(shù)
· 采用體積描記法,直接檢測氣流
· 可選配心血管參數(shù)檢測模塊
主要應用:
· 急性和慢性呼吸道功能障礙模型
· 綜合評價的肺功能
系統(tǒng)采用了尾部外置的特殊描記器,可以通過尾靜脈或頸靜脈對動物進行注射給藥,也可通過霧化的氣溶膠進行吸入式給藥。
具備多種給藥方法:靜脈注射或氣溶膠
氣道阻力與肺順應性檢測體積描計器
根據(jù)需要,可以額外選配心電測量功能:
· 心電圖分析軟件,允許用戶使用特定主題的模板自定義算法??梢愿鼫蚀_的進行分析;
· eDacq ECG 還允許用戶定義自己的 QT 校正因子;
· 可以通過傳統(tǒng)的 ECG 導聯(lián)或遙測獲取信號;
· 目前正在開發(fā) eDacq ECG 以利用新的公式來計算節(jié)拍間的不穩(wěn)定性;
主要檢測參數(shù):
· 氣道阻力 (有/無 插管阻力補償)
· 動態(tài)順應性
· 肋膜壓變化
· Lung conductance
· 潮氣量
· 累計體積
· 吸氣時間
· 呼氣時間
· 吸氣流量
· 呼氣流量
· 呼吸頻率
· 每分通氣量
· 其它參數(shù)
如需方式檢測小動物的肺功能參數(shù),可選擇:
全身體積描記系統(tǒng)
如需檢測更多肺功能參數(shù),可選擇:
多參數(shù)肺功能檢測系統(tǒng)
參考文獻:
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7.Gustafsson ?, Jonasson S, Sandstr?m T, et al. Genetic variation influences immune responses in sensitive rats following exposure to TiO2 nanoparticles[J]. Toxicology, 2014, 326: 74-85.
8.Bradley S J, Wiegman C H, Iglesias M M, et al. Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction[J]. Proceedings of the National Academy of Sciences, 2016, 113(16): 4524-4529.
9.Byrne A J, Weiss M, Mathie S A, et al. A critical role for IRF5 in regulating allergic airway inflammation[J]. Mucosal immunology, 2017, 10(3): 716-726.
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